The Soul Man of G-Funk Nate Dogg has died at the age of 41, his family announced on late Tuesday.

Nathaniel D. Hale, better known as Nate Dogg, was born and raised in Long Beach, Calif. His death was first reported by his hometown newspaper the Press-Telegram, who did not specify the cause of death.

The four-time Grammy nominee appeared on numerous tracks for hip-hop’s biggest stars including Dr. Dre, Eminem, 50 Cent, and Snoop Dogg, and released three solo albums throughout his career.

“R.I.P. TO MY HOMEBOY NATE DOGG DPGC DOGG POUND GANGSTA 4 LIFE,” tweeted his frequent collaborator Daz Dillinger.

Hale suffered two strokes, one in 2007 and another in 2008, and affiliate Warren G had alluded to his health problems in recent days. “For those that dont know awhile back nate had 2 strokes he is in therapy thanks again for your support,” tweeted the Regulator.