More than a dozen of the world’s most accomplished female recording artists—a cast that includes Mariah Carey, Beyoncé, Mary J. Blige, Rihanna, Fergie, Sheryl Crow, Miley Cyrus, Melissa Etheridge, Ashanti, Natasha Bedingfield, Keyshia Cole, Ciara, Leona Lewis, LeAnn Rimes, and Carrie Underwood—have joined together for “Just Stand Up,” an unprecedented charity single in support of Stand Up To Cancer (SU2C), a new initiative to raise philanthropic dollars for accelerating ground-breaking cancer research.

“Just Stand Up” was conceived by Antonio “L.A.” Reid, Chairman, Island Def Jam Music Group, after a powerful and inspiring meeting with the women who organized the Stand Up To Cancer campaign. The song was produced by L.A. and Kenny “Babyface” Edmonds—their first creative reunion on record in nearly two decades. “Just Stand Up” will be released to radio and will be available to purchase exclusively on the iTunes Store starting September 2nd.

“Just Stand Up” is all about the singers and the composers banding together behind SU2C’s mission: rallying the public around the goal of ending cancer’s reign as a leading cause of death. The all-star television performance premiere of the song will take place live on Friday, September 5th (8 p.m. EDT and PDT), when ABC, CBS, and NBC simultaneously devote one hour of commercial-free prime-time to this nationwide event. This will be the first simultaneous cross-network broadcast ever to raise funds for the fight against a disease.